应豪  /  主任医师

—— 博士生导师 ——

学术学位/专业学位

—— 博士生招生专业 ——

妇产科学

—— 硕士生导师 ——

学术学位/专业学位

—— 硕士生招生专业 ——

妇产科学

—— 研究方向 ——

分娩启动与早产；胎盘相关疾病；产科内分泌

preterm labour; placental related disease; obstetrical endocrine

—— 学术任职 ——

上海市第一妇婴保健院党委书记，十四五国家重点研发计划首席科学家，上海市优秀学术带头人，上海市首届医务工匠。第十届中华医学会围产医学分会常委、第四届中国医师协会妇产科医师分会委员，上海市产科临床质量控制中心主任、上海市市级医院产科专科联盟主任，上海医学会围产医学分会候任主任委员，上海市医师协会母胎医学分会副会长、上海市母婴安全委员会副主任委员。上海市医学科技奖青年奖（第一完成人）。临床重点聚焦产科急救、早产、胎盘源性疾病、产科内分泌疾病等。基础研究聚焦早产与分娩启动、滋养细胞侵袭的机制研究。临床研究聚焦围产大数据和模型构建。

—— 科研项目 ——

近三年主持项目：
1、    基于多组学的ART孕妇自发性早产预测指标筛选及评价  临床研究项目（医产融合）  2025-PWYC-07 300万
2、    上海市级医院产科专科联盟  第五批促进临床专科能力提升项目  SHDC22025309 120万
3、    妊娠期子宫颈环扎质量控制规范  标准预研制项目  2025WB16 3万
4、    基于智能手环构建多模态大于胎龄儿预测模型及多中心随机对照临床研究  临床研究项目合作协议  40万
5、    智能穿戴设备居家监测的早期预警对改善妊娠期高血压孕妇的不良妊娠结局多中心  临床研究   16.5万
6、    基于羊膜微环境内细胞互作探究PAI-1介导上皮细胞衰老调控分娩启动的机制  面上项目  82471728 49万
7、    基于早产专病队列构建孕激素栓剂精准使用的决策工具及其效能评价  面上项目  202440190 50万
8、    脯氨酸羟化酶介导的AA代谢关键基因表观遗传重塑在自发性早产中的作用及机制研究  优秀学术带头人  23XD1402700 40万
9、    PAI-1促进羊膜上皮细胞衰老诱导无菌性炎症在分娩启动中的作用机制研究  东方英才拔尖   30万

 

—— 学术论文 ——

近三年代表性论文：
1、    Lv M, Jia Y, Dong J, Wu S, Ying H. The landscape of decidual immune cells at the maternal-fetal interface in parturition and preterm birth. Inflamm Res. 2025 Mar 4;74(1):44. doi: 10.1007/s00011-025-02015-6. PMID: 40038160; PMCID: PMC11880140.
2、    Jia Y, Xie H, Wu S, Dong J, Ying H. Induction of FAM46C expression mediated by DNMT3A downregulation is involved in early-onset preeclampsia through gene body methylation. Cell Signal. 2025 Jan;125:111506. doi: 10.1016/j.cellsig.2024.111506. Epub 2024 Nov 10. PMID: 39532219.
3、    Ling LJ, Li MD, Lu JW, Zhang F, Pan F, Su Y, Myatt L, Wang WS, Sun K, Ying H. Induction of epithelial cell senescence by SERPINE1 derived from fibroblasts in the amnion at parturition. Mech Ageing Dev. 2025 Jun;225:112053. doi: 10.1016/j.mad.2025.112053. Epub 2025 Mar 23. PMID: 40132749.
4、    Xu C, Su Y, Lu W, Dong J, Wang L, Mi Y, Jia X, Lv W, Wu S, Jia Y, Ying H. Estrogen protects against postpartum Concanavalin A-induced hepatitis by promoting intrahepatic CD4⁺CD25⁺ Treg expansion through activation of the PI3K/Akt signaling pathway in HBV-Tg mice. Virol J. 2025 Jul 18;22(1):245. doi: 10.1186/s12985-025-02879-4. PMID: 40682191; PMCID: PMC12273371.
5、    Cao Z, Wang T, Qu X, Dong J, Wu S, Bao Y, Li J, Ying H. Comparative effectiveness of different glycemic criteria for the diagnosis of gestational diabetes mellitus: a target trial emulation. Diabetes Res Clin Pract. 2025 Jul;225:112283. doi: 10.1016/j.diabres.2025.112283. Epub 2025 May 26. PMID: 40436352.
6、    Wu S, Dong J, Shi J, Qu X, Bao Y, Mao X, Lv M, Chen X, Ying H. Machine Learning Prediction of Short Cervix in Mid-Pregnancy Based on Multimodal Data from the First-Trimester Screening Period: An Observational Study in a High-Risk Population. Biomedicines. 2025 Aug 23;13(9):2057. doi: 10.3390/biomedicines13092057. PMID: 41007621; PMCID: PMC12467863.
7、    Xie H, Jiang X, Bao Y, Cao Z, Qu X, Wu S, Dong J, Mao X, Ying H. Asymptomatic twin pregnancies with newly short cervix at 24-276/7 weeks' gestation based on dynamic series follow-up findings: is cervical cerclage necessary? Arch Gynecol Obstet. 2025 Nov;312(5):1613-1620. doi: 10.1007/s00404-025-08165-6. Epub 2025 Aug 27. PMID: 40859045; PMCID: PMC12589290.
8、    Yao X, Bao Y, Wu N, Shan S, Xu Y, Huo K, Huang R, Ying H. Interpretable machine-learning-based prediction of postpartum haemorrhage in normal vaginal births in Shanghai, China. Front Med (Lausanne). 2025 Oct 15;12:1670987. doi: 10.3389/fmed.2025.1670987. PMID: 41169431; PMCID: PMC12570276.
9、    Wu N, Wang L, Li L, Ying H. Massive vulvar edema associated with severe preeclampsia during pregnancy: A case report. Asian J Surg. 2024 Oct;47(10):4382-4383. doi: 10.1016/j.asjsur.2024.07.163. Epub 2024 Jul 26. PMID: 39068072.
10、    Liu X, Huang D, Liu Y, Qu C, Mo H, Zhao X, Li W, Mol BW, Shen H, Cheng W, Ying H. Vaginal dinoprostone vs Foley catheter for induction of labor at term with an unfavorable cervix: an open-label randomized controlled trial. Am J Obstet Gynecol MFM. 2024 Sep;6(9):101436. doi: 10.1016/j.ajogmf.2024.101436. Epub 2024 Aug 2. PMID: 39096968.
11、    Jia Y, Lu W, Xie H, Sheng Y, Wang L, Lv W, Ling L, Dong J, Jia X, Wu S, Liu W, Ying H. Upregulation of Siglec-6 induces mitochondrial dysfunction by promoting GPR20 expression in early-onset preeclampsia. J Transl Med. 2024 Jul 22;22(1):674. doi: 10.1186/s12967-024-05505-z. PMID: 39039496; PMCID: PMC11265165.
12、    Lu C, Luo H, Wang Y, Jing S, Zhao J, Zou K, Wu F, Ying H. Regulation of PDGFRα+ cells and ICC in progesterone-mediated slow colon transit in pregnant mice. Heliyon. 2024 Jan 28;10(3):e25227. doi: 10.1016/j.heliyon.2024.e25227. PMID: 38333873; PMCID: PMC10850515.
13、    Tang Y, Bao Y, Jiang X, Xie H, Cao Z, Qu X, Mao X, Ying H. Cervical dilation after initial cervical cerclage in twin pregnancies: is repeat cerclage beneficial? Am J Obstet Gynecol MFM. 2024 Mar;6(3):101305. doi: 10.1016/j.ajogmf.2024.101305. Epub 2024 Jan 30. PMID: 38301998.
14、    Wu M, Hu C, Huang D, Ying H, Hua J. Fetal sexual dimorphism of maternal thyroid function parameters during pregnancy, a single center retrospective real-world study. Front Endocrinol (Lausanne). 2024 Aug 16;15:1431621. doi: 10.3389/fendo.2024.1431621. PMID: 39220360; PMCID: PMC11365044.
15、    Jiang H, Guo J, Li J, Li C, Du W, Canavese F, Xie F, Li H, Yang J, Ying H, Hua J. Do birth outcomes mediate the association between drug use in pregnancy and neonatal metabolic bone disease? A prospective cohort study of 10,801 Chinese women. Front Public Health. 2024 Sep 30;12:1377070. doi: 10.3389/fpubh.2024.1377070. PMID: 39403442; PMCID: PMC11472830.
16、    Chen L, Cao Z, Qiao P, Liu X, Ying H. Impact of inter-twin growth discordance on preeclampsia: based on ultrasonic estimated fetal weight. Hypertens Res. 2025 Mar;48(3):894-903. doi: 10.1038/s41440-024-02027-5. Epub 2024 Dec 4. PMID: 39627393; PMCID: PMC11879843.
17、    Lv W, Xie H, Wu S, Dong J, Jia Y, Ying H. Identification of key metabolism-related genes and pathways in spontaneous preterm birth: combining bioinformatic analysis and machine learning. Front Endocrinol (Lausanne). 2024 Aug 20;15:1440436. doi: 10.3389/fendo.2024.1440436. PMID: 39229380; PMCID: PMC11368757.
18、    Ling LJ, Zhou Q, Zhang F, Lei WJ, Li MD, Lu JW, Wang WS, Sun K, Ying H. The dual role of glucocorticoid regeneration in inflammation at parturition. Front Immunol. 2024 Sep 3;15:1459489. doi: 10.3389/fimmu.2024.1459489. PMID: 39290694; PMCID: PMC11405189.
19、    Wu S, Xie H, Su Y, Jia X, Mi Y, Jia Y, Ying H. The landscape of implantation and placentation: deciphering the function of dynamic RNA methylation at the maternal-fetal interface. Front Endocrinol (Lausanne). 2023 Aug 30;14:1205408. doi: 10.3389/fendo.2023.1205408. PMID: 37720526; PMCID: PMC10499623.
20、    Li X, Xie H, Chao JJ, Jia YH, Zuo J, An YP, Bao YR, Jiang X, Ying H. Profiles and integration of the gut microbiome and fecal metabolites in severe intrahepatic cholestasis of pregnancy. BMC Microbiol. 2023 Oct 3;23(1):282. doi: 10.1186/s12866-023-02983-x. PMID: 37784030; PMCID: PMC10546765.
21、    Wu S, Wang L, Dong J, Bao Y, Liu X, Li Y, Liu X, Xie H, Ying H. The dose- and time-dependent effectiveness and safety associated with COVID-19 vaccination during pregnancy: a systematic review and meta-analysis. Int J Infect Dis. 2023 Mar;128:335-346. doi: 10.1016/j.ijid.2023.01.018. Epub 2023 Jan 25. PMID: 36707044; PMCID: PMC9873368.
22、    Jiang H, Guo J, Li J, Li C, Du W, Canavese F, Baker C, Ying H, Hua J. Artificial Neural Network Modeling to Predict Neonatal Metabolic Bone Disease in the Prenatal and Postnatal Periods. JAMA Netw Open. 2023 Jan 3;6(1):e2251849. doi: 10.1001/jamanetworkopen.2022.51849. PMID: 36689226; PMCID: PMC9871802.