花静  /  主任医师

—— 博士生导师 ——

学术型博导/专业型博导

—— 博士生招生专业 ——

儿科学

—— 硕士生导师 ——

学术型硕导

—— 硕士生招生专业 ——

儿科学

—— 研究方向 ——

发育行为儿科（含儿科+心理中英双博士学位培养） 围产流行病学.

—— 学术任职 ——

中国预防医学会 体育与健康分会 委员 中华预防医学会 生育力保护分会 委员 中国妇幼保健协会 儿童早期发展分会委员 中华医学会 公共卫生分会 临床与预防专委会 委员 上海市营养学会 理事 上海市优生优育协会 妇幼保健分会 委员 中国妇幼健康研究杂志、中国妇幼卫生杂志和中国儿童保健杂志编委、特邀编委和青年等职

—— 科研项目 ——

国家自然科学基金委员会，面上项目，82473638，大气NPs共污染致胎-婴小脑铁代谢失稳态预测发育性协调障碍成年期发展，2025-01至2028-12, 49万，主持 上海市卫生健康委员会医学新技术研究与转化种子计划重点项目，“巨大儿”发育性协调障碍生命早期功能-影像多模态预测研究和AI“动力链”转化平台建设，2024ZZ1016，160万，主持 国家自然科学基金委员会面上项目，81673179，DNA甲基化动态修饰介导的“早期儿”认知-运动障碍预警评估模式研究，2017/01-2020/12，49万，主持 国家自然科学基金委员会青年项目，81402687，孕期PM2.5自然暴露模式对子代认知-运动发育的影响及表观修饰机制研究，2015/01-2017/12，19万，主持 上海市科学技术委员会，技术标准类课题，21DZ2202000，儿童发育性协调障碍早期筛查及整合运动干预标准化模式建设，2021-10至2024-9, 15万，主持 主持上海市科学技术委员会动物实验课题，19140903100，孕鼠PM2.5“自然暴露”致甲状腺素表观调控通路失稳态及介导子代神经行为障碍模型研究，2019/05-2022/04,30万 上海市科学技术委员会动物实验课题，18140903100，PM2.5浓缩仓暴露致不育症小鼠及不同“减”污染模式下表观跨代遗传模型，2018/05-2021/04，30万，主持 上海市科学技术委员会重点课题（长三角联合攻关项目），15495810500，名称：长三角“智慧保健”-婴幼儿智护体系建设关键筛查技术研究及示范应用，2015/06-2017/06，80万，主持 上海市科学技术委员会引导类项目，14411970900,名称：高危儿发育性运动协调障碍预警评估及生态干预模式研究，2014/08-2017/09，30万，主持 上海市卫生健康委老龄化和妇儿健康研究专项2020YJZX0213，孤独症合并运动协调障碍“动力系统”超早期干预模式研究， 2020/08-2023/07 100万，主持 上海申康医院发展中心临床三年行动计划SHDC2020CR1047B，早产儿神经发育迟缓精准评价与预测的多中心研究，2020.10.1-2023.10，74万，在研，主持 浦东新区卫生健康委员会联合攻关项目，围孕期亚临床型甲状腺疾病致子代发育性协调障碍“妇幼整 链式”预警评估模式建设，2020/07-2023/06，30万，主持 上海市申康医院发展中心适宜技术联合开发推广应用项目，SHDC12016239，早期儿发育性运动协调障碍三阶“级-联”筛查模式研究及临床应用，10万，主持2016/11-2019/11，10万，主持 主持浦东新区卫生局卫生（计生）科技项目，PW2013-D9、孕产期PM2.5相关疾病预警预报技术和应用效果研究、2013/07-2016/07、10万，主持。

—— 学术论文 ——

1. Chen Z., Yang J., Gao B., Zuyi Fang3, Weihua Dong, Wenchong Du, Manchun Li, Xiao Chen, Chaoqun Zhang, Jing Hua. Multi-scale social-economic-environmental inequities lead to heterogeneity of Developmental Coordination Disorder risk across China. The Innovation Medicine 3(1): 100109, February 27, 2025. 2. Rong M, Shen Y, Ge Y, Du W, Kan H, Cai J, Zhao Y, Hua J*. Association between Ambient Ultrafine Particles and Neurodevelopmental Delay in Preschoolers in Shanghai, China. Environ Health (Wash). 2024 Oct 1;3(1):102-110. doi: 10.1021/envhealth.4c00102. PMID: 39839251; PMCID: PMC11744390. 3. Mengxun Rong, Yang Shen, Yihui Ge, Wenchong Du, Haidong Kan, Jing Cai*, Yan Zhao*, and Jing Hua* Association between Ambient Ultrafine Particles and Neurodevelopmental Delay in Preschoolers in Shanghai, China, Environment & Health Article ASAP DOI: 10.1021/envhealth.4c00102 4. Jiang H, Guo J, Li J, Li C, Du W, Canavese F, Xie F, Li H, Yang J, Ying H*, Hua J*. Do birth outcomes mediate the association between drug use in pregnancy and neonatal metabolic bone disease? A prospective cohort study of 10,801 Chinese women. Front Public Health. 2024 Sep 30;12:1377070. doi: 10.3389/fpubh.2024.1377070. PMID: 39403442; PMCID: PMC11472830. 5. Suhaimi MA, Zheng Y, You H, Su Y, Williams GJ, Gupta MP, Du W*, Hua J*. Association between postterm birth and adverse growth outcomes in children aged 3-6 years: A national retrospective cohort study. Paediatr Perinat Epidemiol. 2024 Sep 19. doi: 10.1111/ppe.13122. Epub ahead of print. PMID: 39297305. 6. Dai X, Williams GJ, Groeger JA, Jones G, Brookes K, Zhou W, Hua J*, Du W. The role of circadian rhythms and sleep in the aetiology of autism spectrum disorder and attention-deficit/hyperactivity disorder: New evidence from bidirectional two-sample Mendelian randomization analysis. Autism. 2024 Jun 13:13623613241258546. 7. Hua J*, Rihtman T, Peng Y, Wang T, Su Y, Du W*. Assessing the usefulness of the Little Developmental Coordination Disorder Questionnaire-Chinese in Chinese preschoolers: a sex-and age-specific analysis. Front Psychol. 2024 Jan 30;15:1321342. 8. Wu M, Hu C, Huang D, Ying H*, Hua J*. Fetal sexual dimorphism of maternal thyroid function parameters during pregnancy, a single center retrospective real-world study. Front Endocrinol (Lausanne). 2024 Aug 16;15:1431621. 9. Cai J, Shen Y, Meng X, Zhao Y, Niu Y, Chen R, Du W, Quan G, Barnett AL, Jones G, Kan H*, Hua J*. Association of developmental coordination disorder with early-life exposure to fine particulate matter in Chinese preschoolers. Innovation (Camb). 2022 Nov 4;4(1):100347. eCollection 2023 Jan 30. doi: 32.10.1016/j.xinn.2022.100347. PMID: 36425095; PMCID: PMC9678769. 32.1 10. Geng S, Wang W, Huang L, Xie J, Williams GJ, Baker C, Du W, Hua J*. Association between screen time and suspected developmental coordination disorder in preschoolers: A national population-based study in China. Front Public Health. 2023 Mar 27;11:1152321. doi: 10.3389/fpubh.2023.1152321. PMID: 37050955; PMCID: PMC10083417. 11. Hua J*, Rihtman T, Peng Y, Wang T, Su Y, Du W. Assessing the usefulness of the Little Developmental Coordination Disorder Questionnaire-Chinese in Chinese preschoolers: a sex-and age-specific analysis. Front Psychol. 2024 Jan 30;15:1321342. doi: 10.3389/fpsyg.2024.1321342. PMID: 38352027; PMCID: PMC10861738.Format: 12. Dai X, Williams GJ, Groeger JA, Jones G, Brookes K, Zhou W, Hua J*, Du W*. The role of circadian rhythms and sleep in the aetiology of autism spectrum disorder and attention-deficit/hyperactivity disorder: New evidence from bidirectional two-sample Mendelian randomization analysis. Autism. 2024 Jun 13:13623613241258546. doi: 10.1177/13623613241258546. Epub ahead of print. PMID: 38869021. 13. You H, Shi J, Huang F, Wei Z, Jones G, Du W, Hua J*. Advances in Genetics and Epigenetics of Developmental Coordination Disorder in Children. Brain Sci. 2023 Jun 11;13(6):940. doi: 10.3390/brainsci13060940. PMID: 37371418; PMCID: PMC10296699. 14. Jiang H, Guo J, Li J, Li C, Du W, Canavese F, Baker C, Ying H, Hua J*. Artificial Neural Network Modeling to Predict Neonatal Metabolic Bone Disease in the Prenatal and Postnatal Periods. JAMA Netw Open. 2023 Jan 3;6(1):e2251849. doi: 10.1001/jamanetworkopen.2022.51849. PMID: 36689226.Format: IF 13.353 15. Yang Y, Yang T, Zhou J, Cao Z, Liao Z, Zhao Y, Su X, He J, Hua J*. Prenatal exposure to concentrated ambient PM2.5 results in spatial memory defects regulated by DNA methylation in male mice offspring. Environ Sci Pollut Res Int. 2023 Mar;30(12):35142-35152. doi: 10.1007/s11356-022-24663-5. Epub 2022 Dec 17. PMID: 36526934; PMCID: PMC10017658. Format:. IF 5.190 16. Cai J, Shen Y, Zhao Y, Meng X, Niu Y, Chen R, Quan G, Li H, Groeger JA, Du W, Hua J*, Kan H. Early Life Exposure to PM2.5 and Sleep Disturbances in Preschoolers from 551 Cities of China. Am J Respir Crit Care Med. 2022 Sep 28. doi: 10.1164/rccm.202204-0740OC. Epub ahead of print. PMID: 36170612. IF 30.528 17. Hua J*, Xie J, Baker C, Du W. National Prevalence of Excessive Screen Exposure Among Chinese Preschoolers. JAMA Netw Open. 2022 Jul 1;5(7):e2224244. doi: 10.1001/jamanetworkopen.2022.24244. PMID: 35900767. IF 13.353 18. Hua J*, Barnett AL, Williams GJ, Dai X, Sun Y, Li H, Chen G, Wang L, Feng J, Liu Y, Zhang L, Zhu L, Weng T, Guan H, Gu Y, Zhou Y, Butcher A, Du W. Association of Gestational Age at Birth With Subsequent Suspected Developmental Coordination Disorder in Early Childhood in China. JAMA Netw Open. 2021 Dec 1;4(12):e2137581. doi: 10.1001/jamanetworkopen.2021.37581. PMID: 34905005; PMCID: PMC8672235.Format: 2021;4(12):e2137581.doi:10.1001/jamanetworkopen.2021.37581 IF 13.353 19. Lyu J, Groeger JA, Barnett AL, Li H, Wang L, Zhang J, Du W, Hua J*. Associations between gestational age and childhood sleep: a national retrospective cohort study. BMC Med. 2022 Aug 8;20(1):253. doi: 10.1186/s12916-022-02443-9. PMID: 35934710; PMCID: PMC9358861 IF 11.15 20. Liu MX, Li HF, Wu MQ, Geng SS, Ke L, Lou BW, Du W*, Hua J*. Associations of preterm and early-term birth with suspected developmental coordination disorder: a national retrospective cohort study in children aged 3-10 years. World J Pediatr. 2022 Dec 5. doi: 10.1007/s12519-022-00648-9. Epub ahead of print. PMID: 36469242. IF 9.186 21. Zhang J, Yang Y, Al-Ahmady ZS, Du W, Duan J, Liao Z, Sun Q, Wei Z, Hua J. Maternal exposure to PM2.5 induces cognitive impairment in offspring via cerebellar neuroinflammation and oxidative stress. Ecotoxicol Environ Saf. 2023 Jan 1;249:114425. doi: 10.1016/j.ecoenv.2022.114425. Epub 2022 Dec 19. PMID: 38321695.Format:IF 7.129 22. Wu M, Williams GJ, Chen G, Zhang L, Hu C, Dai X, Du W*, Hua J*. Prenatal second-hand smoke exposure and the risk of suspected developmental coordination disorder in preschoolers: A nationwide retrospective cohort study in China. Front Public Health. 2022 Nov 8;10:993471. doi: 10.3389/fpubh.2022.993471. PMID: 36438244; PMCID: PMC9686837. IF 6.461 23. Hua J*, Williams GJ, Barnett AL, Zhang J, Jin H, Xu M, Chen J, Zhou Y, Gu G, Du W*. Association of the Onset of Self-Feeding With Subsequent Suspected Developmental Coordination Disorder: A Prospective Cohort Study in China. Front Psychiatry. 2022 May 6;13:818771. doi: 10.3389/fpsyt.2022.818771. PMID: 35599757; PMCID: PMC9120420.Format:IF 5.435 24. Hua J*, Williams GJ, Jin H, Chen J, Xu M, Zhou Y, Gu G, Du W: Early Motor Milestones in Infancy and Later Motor Impairments: A Population-Based Data Linkage Study. Front Psychiatry 2022, 13:809181. IF 5.435 25. Hua J*, Barnett AL, Williams GJ, Dai X, Sun Y, Li H, Chen G, Wang L, Feng J, Liu Y, Zhang L, Zhu L, Weng T, Guan H, Gu Y, Zhou Y, Butcher A, Du W*. Association of Gestational Age at Birth With Subsequent Suspected Developmental Coordination Disorder in Early Childhood in China. JAMA Netw Open. 2021 Dec 1;4(12):e2137581. doi: 10.1001/jamanetworkopen.2021.37581. PMID: 34905005; PMCID: PMC8672235. 26. Dai X, Williams G, Lin S, Baker C, Wu M, Du W, Hua J*. The sibling effect on neurodevelopment of preschoolers under China's newly relaxed child policy: A national retrospective cohort study. Front Psychol. 2022 Dec 6;13:988622. doi: 10.3389/fpsyg.2022.988622. PMID: 36562065; PMCID: PMC9764001.Format: 27. Hua J, Barnett AL, Lin Y, Guan H, Sun Y, Williams GJ, Fu Y, Zhou Y, Du W. Association of Gestational Age at Birth With Subsequent Neurodevelopment in Early Childhood: A National Retrospective Cohort Study in China. Front Pediatr. 2022 May 31;10:860192. doi: 10.3389/fped.2022.860192. PMID: 35712637; PMCID: PMC9194570. 28. Hua J*, Lyu J, Du W. Prevalence of Sleep Disorder in Chinese Preschoolers: A National Population-Based Study. Nat Sci Sleep. 2022 Nov 24;14:2091-2095. doi: 10.2147/NSS.S383209. PMID: 36452478; PMCID: PMC9704014. 29. Zhang J, Williams GJ, Wang G, Chen J, Zhang M, Du W, Zhu J, Zhang J, Hua J*: Early-term birth and its association with universal two-child policy: a national cross-sectional study in China. BMJ Open 2021, 11(12):e054959. IF 3.006 30. Yuantong Sun, Weiwei Zheng, Ling Zhang, Huijuan Zhao, Xun Li, Chao Zhang, Wuren Ma, Dajun Tian, Kun-Hsing Yu, Shuo Xiao, Liping Jin, Jing Hua*. Quantifying the Impacts of Pre- and Post-Conception TSH Levels on Birth Outcomes: An Examination of Different Machine Learning Models. Front. Endocrinol., 29 October 2021 doi:https://doi.org/10.3389/fendo.2021.a755364 31. Hua J*, Shen J, Zhang J, Zhou Y, Du W, Williams GJ: The association between COVID-19 pandemic and maternal isolated hypothyroxinemia in first and second trimesters. Psychoneuroendocrinology 2021, 128:105210 32. Liu M, Xue M, Yang Q, Du W, Yan X, Tan J, Duan T, Hua J*: Association between migration status and caesarean section delivery based on a modified Robson classification in China. BMC Pregnancy Childbirth 2021, 21(1):215. 33. Yang Y, Le Ray I, Zhu J, Zhang J, Hua J*, Reilly M*. Preeclampsia Prevalence, Risk Factors, and Pregnancy Outcomes in Sweden and China. JAMA Netw Open. May 3 2021;4(5):e218401. doi:10.1001/jamanetworkopen.2021.8401 34. Cao Z, Su X, Ni Y, Luo T, Hua J*. Association between the home environment and development among 3- to 11-month infants in Shanghai, China. Child: care, health and development. Jul 28 2021;doi:10.1111/cch.12902 Zhi-juan Cao, Yan Zhao, Shu-mei Wang, Dong-lan Zhang, Ying-chun Zhou, Wen-na Liu, Ying-ying Yang, Jing Hua*. Prenatal exposure to fine particulate matter and fetal growth: a cohort study from a velocity perspective. Chemosphere 262 (2021) 128404. doi:10.1016/j.chemosphere.2020.128404 35. Xiujuan Su, Yan Zhao, Yingying Yang, Jing Hua*. Correlation between exposure to fine particulate matter and hypertensive disorders of pregnancy in Shanghai, China. Environ Health. 2020 Sep 17;19(1):101. doi: 10.1186/s12940-020-00655-1. Zhao Y, Cao Z, Li H, Su X, Yang Y, Liu C, Hua J*: Air pollution exposure in association with maternal thyroid function during early pregnancy. J Hazard Mater 2019, 367:188-193. 36. Cai J, Zhao Y, Kan J, Chen R, Martin R, van Donkelaar A, Ao J, Zhang J, Kan H*, Hua J*. Prenatal Exposure to Specific PM 2.5 Chemical Constituents and Preterm Birth in China: A Nationwide Cohort Study. Environ Sci Technol. 2020 Nov 17;54(22):14494-14501. doi: 10.1021/acs.est.0c02373. 37. Yan Zhao , Jing Cai, Xinlei Zhu, Aaron van Donkelaar , Randall V Martin, Jing Hua*, Haidong Kan*. Fine particulate matter exposure and renal function. Environ Int. 2020 Aug;141:105805. doi:10.1016/j.envint.2020.105805. Epub 2020 May 29 38. Jing Hua*, Wenchong Du*, Xiaotian Dai, Meiqin Wu, Xianying Cai, Min Shen, Liping Zhu International clinical practice recommendations on the definition, diagnosis, assessment, intervention, and psychosocial aspects of developmental coordination disorder – Chinese (Mandarin) translation. Developmental Medicine & Child Neurology, 2020. DOI: 10.1111/dmcn.14693 IF 4.864 39. Jiajun Lyu, Qingqing Zhu, Shilu Tong, Xiujuan Su, Shenghui Li*, Jing Hua*. Trajectories of sleep quality and associations with excessive gestational weight gain during pregnancy. Sleep and Biological Rhythms. 2020, March, https://doi.org/10.1007/s41105-020-00266-w 40. Jing Hua*, Yu Li, Kan Ye,Yujie Ma,Senran Lin , Guixiong Gu, Wenchong Du. The reliability and validity of Bayley-III cognitive scale in China’s male and female children. Early Human Development. 2019,129,71-78. 41. Jing Hua*, Jie Sun, Zhijuan Cao, Xiaotian Dai, Senran Lin, Jialin Guo, Guixiong Gu, Wenchong Du. Differentiating the cognitive development of early-term births in infants and toddlers: a cross-sectional study in China. BMJ Open 2019, 2019 Apr 11;9(4): e025275. 42. Yang Y, Yang T, Liu S, Cao Z, Zhao Y, Su X, Liao Z, Teng X, Hua J*. Concentrated ambient PM2.5 exposure affects mice sperm quality and testosterone biosynthesis. PeerJ. 2019 Nov 28;7:e8109. doi: 10.7717/peerj.8109. eCollection 2019. 43. Mei-Qin Wu*, Jin Liu*, Ya-Qian Wang, Ying Yang, Chong-Huai Yan, Jing Hua*. The Role of Thyroid Screening in Pregnancy. Frontiers in Endocrinology 2019, 8（10）Article522 44. Cao Z#, Meng L#, Zhao Y, Liu C2, Yang Y, Su X, Fu Q, Wang D, Hua J*. Maternal exposure to ambient fine particulate matter and fetal growth in Shanghai, China. Environ Health. 2019 May 16;18(1):49. doi: 10.1186/s12940-019-0485-3.

—— 其他成果 ——

国家发明专利：预测发育性协调障碍的方法、装置及电子设备 软件著作权：《3-15岁儿童发育性协调障碍问卷中国常模》，已转化190万 上海市东方英才计划“拔尖人才” 上海市第十七届医学科技奖三等奖，第一完成人 第四届全国妇幼健康科学技术奖 三等奖，第一完成人 上海市静安区首届中青年拔尖人才 2018年 上海市女医师协会第二届“医树奖”医学科普创新奖三等奖