学术型硕导
妇产科学
子宫内膜纤维化的表观遗传调控机制
1.国家自然科学基金-面上项目 PUM1调控胎盘滋养层细胞侵袭和增殖的机制研究 2021.01-2024.12 经费:55万,结题,主持 2.同济大学基本科研业务费项目-重点项目 Rabdosiin靶向表观遗传调控因子BAZ2B干预宫腔粘连疾病的探索性研究2024.04-2027.03经费:25万,在研,主持
1.Xiao M, Zheng Y, Wang MX, Sun YH, Chen J, Zhu KY, Zhang F, Tang YH, Yang F, Zhou T, Zhang YP, Lei CX, Sun XX, Yu SH, Tian FJ*. Elevated histone demethylase KDM5C increases recurrent miscarriage risk by preventing trophoblast proliferation and invasion. Cell Death Discov. 2022 Dec 22;8(1):495. 2.Wei XW, Liu XQ, Zhang YC, Qin CM, Lin Y, Tian FJ*. TCF3 regulates human endometrial stromal cell proliferation and migration in RPL. Reproduction. 2022;163(5):281-291. 3.Zhang YC, Qin XL, Ma XL, Mo HQ, Qin S, Zhang CX, Wei XW, Liu XQ, Zhang Y, Tian FJ*, Lin Y*. CLDN1 regulates trophoblast apoptosis and proliferation in preeclampsia. Reproduction. 2021;161(6):623-632. 4.Zhang Y, He XY, Qin S, Mo HQ, Li X, Wu F, Zhang J, Li X, Mao L, Peng YQ, Guo YN, Lin Y, Tian FJ*. Upregulation of Pumilio 1 expression in preeclampsia impairs trophoblast invasion by negatively regulating the expression of the lncRNA HOTAIR. Mol Ther. 2020;28(2):631-641. 5.Li XC, Jin F, Wang BY, Yin XJ, Hong W, Tian FJ*. The m6A demethylase ALKBH5 controls trophoblast invasion at the maternal-fetal interface by regulating the stability of CYR61 mRNA. Theranostics 2019; 9: 3853-3865.
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