杜彬  /  主任医师

—— 博士生导师 ——

专业型博导

—— 博士生招生专业 ——

临床病理

—— 硕士生导师 ——

学术型硕导

—— 硕士生招生专业 ——

肿瘤学

—— 研究方向 ——

以肿瘤病理学为主要研究领域，聚焦于化疗药物诱导的多种细胞死亡形式的分子机制，关注基因调控与细胞周期进展，从表观遗传修饰的角度探讨肿瘤增殖及治疗抵抗的病理机制，并研发靶向干预策略。 Dr. Du specializes in tumor pathology, focusing on the molecular mechanisms underlying various forms of cell death induced by chemotherapeutic agents. His research also emphasizes gene regulation and cell cycle progression, exploring the pathological mechanisms of tumor proliferation and treatment resistance from the perspective of epigenetic modification, and developing targeted intervention strategies.

—— 学术任职 ——

任职： 同济大学附属第一妇婴保健院病理科主任 中国抗癌协会肿瘤病理专委会委员 上海市病理学会分子病理学组委员 Director of the Department of Pathology, First Maternity and Infant Health Hospital Affiliated to Tongji University Member of the Tumor Pathology Committee, Chinese Anti-Cancer Association Member of the Molecular Pathology Group, Shanghai Society of Pathology

—— 科研项目 ——

主持科研项目： （1）课题号：24ZR1458100，课题名称：线粒体RNA触发免疫应答在烷化剂免疫原性化疗中的作用及机制。上海市自然科学基金项目，20万 （2）国家自然科学基金委员会，面上项目，FTO在蒽环类药物诱导的乳腺癌免疫性细胞死亡中的作用及机制，2019-01-01至2022-12-31，结题 （3）国家自然科学基金委员会，青年科学基金项目，Snai1/slug-miR30a反馈环路对肾小管上皮细胞间质转化调控，2013-01-01至2015-12-31，结题

—— 学术论文 ——

(1)Tao S; Xie SJ; Diao LT; Lv G; Hou YR; Hu YX; Xu WY; Du B*; Xiao ZD*. RNA-binding protein CCDC137 activates AKT signaling and promotes hepatocellular carcinoma through a novel non-canonical role of DGCR8 in mRNA localization, J Exp Clin Cancer Res., 2023;42(1):194 (2)Jiang S; Wang H; Zhu J; Xu X; Chen L; Wang B; Zhou B; Zhu Y; Zhang Z; Ma B*; Du B*; Yang Y*. Identify the Clinicopathological Characteristics of Lung Carcinoma Patients Being False Negative in Folate Receptor Based Circulating Tumor Cell Detection. Small Methods. 2023;7(9):e2300055 (3)Qu J; Yu J; Zhong S; Wang W; Wang Q; Du B. The presence of clear cell glands around the ovarian endometrioid cyst has an association with clear cell carcinoma. Virchows Arch., 2023;482(6):1021-1034 (4)Shi H; Hou B; Li H; Zhou H; Du B. Cyclophosphamide Induces the Ferroptosis of Tumor Cells Through Heme Oxygenase-1, Front. Pharmacol., 2022, 13: 839464 (5)Li H; Zhong Y; Cao G; Shi H; Liu Y; Li L; Yin P; Chen J; Xiao Z*; Du B*. METTL3 promotes cell cycle progression via m6A/YTHDF1-dependent regulation of CDC25B translation, Int J Biol Sci., 2022, 18(8): 3223-3236 (6)Hu J; Yu X; Yin P; Du B*; Cai X*. Intravoxel Incoherent Motion Diffusion- Weighted MR Imaging for Monitoring the Immune Response of Immunogenic Chemotherapy. Front Oncol. 2022;12:796936. (7)Du B; Waxman DJ; Medium dose intermittent cyclophosphamide induces immunogenic cell death and cancer cell autonomous type I interferon production in glioma models. Cancer Lett., 2020;470:170-180 (8)Yin P; Li H; Ke C; Cao G; Xin X; Hu J; Cai X; Li L; Liu X*; Du B*. Intranasal Delivery of Immunotherapeutic Nanoformulations for Treatment of Glioma Through in situ Activation of Immune Response [published correction appears in Int J Nanomedicine. 2020, 15:8873-8874

—— 其他成果 ——

(1) 杜彬; 殷培迪; 李惠峰; 曹广旭; 陈嘉玲; AuNP@PP/poly(I:C)及其制备方法与其在制备治疗胶质瘤药物中的应用, 2019-6-21,中国, ZL 201910540889.5 (专利)