张海  /  主任药师

—— 博士生导师 ——

学术型博导

—— 博士生招生专业 ——

基础医学/药学

—— 硕士生导师 ——

学术型硕导

—— 硕士生招生专业 ——

药学（学术型）生物与医药（专业型）

—— 研究方向 ——

基于纳米智能生物传感技术的诊疗一体化研究
Research on the integrated treatment of diagnosis and treatment based on nano intelligent biosensing technology

—— 学术任职 ——

医院任职：同济大学附属妇产科医院 药剂科主任
学会任职：中国妇幼保健协会药事管理专业委员会主任委员，上海市药理学会治疗药物监测研究专业委员会副主任委员，上海市药学会医院药学专委会委员
Hospital position: Director of Pharmacy Department, Obstetrics and Gynecology Hospital of Tongji University.
Academic Affiliations:  Chief Member of the Pharmacy Administration Commission of Chinese Maternal and Child Health Association, Deputy Director and Secretary of the Division of Therapeutic Drug Monitoring of Chinese Pharmacological Society, Member of Hospital Pharmacy of Shanghai Pharmaceutical Society

—— 科研项目 ——

作为项目负责人承担国家自然科学基金、上海市科委及卫健委课题项目二十余项，获得上海市人才计划项目2项。
1. 附子中单酯型生物碱类成分靶向RAAS系统中ACE2-Ang(1-7)-Mas轴抗心衰作用机制研究，81973504，2020.1-2023.12，国家自然科学基金面上项目；55万，第1 2. 上海市优秀青年学术带头人，张海，参附汤通过调控RAAS系统中ACE/ACE2双轴平衡抗心衰作用配伍机制研究，2022.9-2025.8，22XD1422200，40万 3. 上海市卫健委-卫生健康学科带头人，张海，中医验方“复原生化颗粒”治疗产后子宫复旧不全的药效成分与配伍机制研究，2023.1-2025.12，2022XD041，45万 4. 妇产科特色验方“复原生化颗粒”治疗产后子宫复旧不全的新药临床前研究，2022.4-2025.3，22S21903000，上海市科委“科技创新行动计划”生物医药科技支撑项目；40万，第1 5. 基于纳米抗体荧光传感技术的血栓筛查与防治标志物一体化监测新方法研究，2023.1-2024.12，22120220633，同济大学基础研究能力提升计划/自主原创重点项目；30万，第1 6. 卵巢癌早期诊断和治疗药物监测新方法开发，2022.9-2025.8，上海市第一妇婴保健院“人才蓄水池”领航计划，60万，第1 7. 暖宫外敷贴预防术后宫腔再粘连的随机对照试验研究，上海市第一妇婴保健院院内培育成果转化项目，2024.6-2027.5，20万，第1

—— 学术论文 ——

1. Jiyang Xue, Hai Zhang*, CXCR4 Blocker-Enriched Paclitaxel-Loaded Multifunctional Nanoparticles for the Targeted Reversal of the Immunosuppressive Microenvironment in Ovarian Cancer Therapy, ACS Appl. Nano Mater. 2024, 7, 20, 23744–23753. (Corresponding author, IF:5.3) 2. Xiaoyi Yin, Gaoning Zhang, Guangxu Song, Xiaoru Li, Xinming Liu, Lufan Wang, Hai Zhang*, Zhixin Tang*, A novel near-infrared fluorescent probe for butyrylcholinesterase: Research for screening of natural anti-AD inhibitors, Analytica Chimica Acta 1331 (2024) 343348. (Corresponding author, IF: 5.7) 3. Qingshan Chen, Yaoqi Sun, Hao Li, Shupeng Liu, Hai Zhang*, Zhongping Cheng*, Yu Wang*, Pixantrone as a novel MCM2 inhibitor for ovarian cancer treatment, European Journal of Pharmacology. 2024 Sep 15:979:176835. (Corresponding author, IF: 4.2) 4. Yidong Cui, Qingming Liu, Qiqiang Zhang, Xuemei Di, Hai Zhang*, Benzoylaconine Protects Skeletal Muscle Against Ischemia-Reperfusion Injury Through Activation of IF1-Dependent AMPK/Nrf2 Axis, Drug Design Development and Therapy, 2024:18 2125–2142. (Corresponding author, IF: 4.8) 5. Xin’er Hu, Diya Lv, Minyu Qi, Ying Zhang, Xiaofei Wang, Jiayu Gu, Dongyao Wang, Xiaofei Chen, Yue Liu, Yan Cao*, Hai Zhang*, New Surface Plasmon Resonance-Based Immunoassay for Rapid and Sensitive Quantification of D-dimer in Human Plasma for Thrombus Screening, Journal of Chromatography B, 2024. (Corresponding author, IF: 3.0) 6. Qi-qiang Zhang, Qing-shan Chen, Fei Feng, Xiang Cao, Xiao-fei Chen*, Hai Zhang*, Benzoylaconitine: A promising ACE2-targeted agonist for enhancing cardiac function in heart failure, Free Radical Biology and Medicine, 2024, 214, 206–218. (Corresponding author, IF: 7.4) 7. Fang Fan#, Xu-Man Chen#, Jieman Lin#, Meiyu Lin, Ling Li, Yanqiu Gu, Yifeng Chai, Hai Zhang*, Xiaofei Chen* and Quan Li*, Advanced Functional Materials, Peptide-Based Organic-Inorganic Hybrid Self-Assemblies for Ultrasensitive and Visual Detection of Heparin, Advanced Functional Materials, 2024, 34, 2314832. (Co-corresponding author, IF:19.0) 8. Jiyang Xue, Zhendong Xu, Xiaobing Hu, Yan Lu, Yan Zhao*, Hai Zhang*, Microplastics in Maternal Amniotic Fluid and Their Associations with Gestational Age, Science of the Total Environment, 2024, 920: 171044. (Corresponding author, IF:9.8) 9. Qi-qiang Zhang, Xue-mei Di, Xiang Cao, Yonghong Nie, Wen Shuai, Jun Li, Hai Zhang*，Analysis of pharmacodynamic components, targets and synergistic action mechanism of Fuyuan Shenghua granule for the treatment of medical-induced incomplete abortion based on network pharmacology, Journal of Ethnopharmacology, 2024, 319(117118). (Corresponding author, IF:5.195) 10. Minyu Qi# , Diya Lv# , Ying Zhang, Dongyao Wang, Yifeng Chai, Hai Zhang*, Yan Cao*, Development of a surface plasmon resonance biosensor for accurate and sensitive quantitation of small molecules in blood samples, Journal of Pharmaceutical analysis, 2022, 12, 926-936. (Co-corresponding author, IF: 14.026) 11. Qi-Qiang Zhang# , Feng-Hua Chen# , Fei Wang, Xue-Mei Di, Wei Li, Hai Zhang*, A novel modulator of renin-angiotensin system, benzoylaconitine, attenuates hypertension by targeting ACE/ACE2 in enhancing vasodilation and alleviating vascular inflammation, Frontiers in Pharmacology, 2022, 13(841435). (Corresponding author, IF: 5.988) 12. Hai-Qiao Wang# , Zhong Wan# , Qiqiang Zhang# , Tong Su, Dan Yu, Fei Wang, Chao Zhang, Wei Li, Dongliang Xu*, Hai Zhang*, Schisandrin B targets cannabinoid 2 receptor in Kupffer cell to ameliorate CCl4-induced liver fibrosis by suppressing NF-κB and p38 MAPK pathway, Phytomedicine, 2022，98，153960. (Corresponding author, IF: 6.656) 13. Jieman Lin, Jie Ding, Xuemei Di, Wenqin Sun, Huifen Chen, Hai Zhang*, Association between prenatal antibiotics exposure and measures of fetal growth: A repeated-measure study, Ecotoxicology and Environmental Safety, 2022,244, 114041. (Corresponding author, IF: 7.129) 14. Yan Zhao, Jie Ding, Lei Lv, Hai Zhang*, 主要从事基于纳米智能生物传感技术的诊疗一体化研究工作，发表相关研究论文100余篇，其中第一或通讯作者SCI论文60余篇，Exposure to organophosphate esters during early pregnancy and risk of spontaneous abortion: a case-control study, Chemosphere, 2021, 268:129375. (Corresponding author, IF:8.943) 15. Kaiyang Chen#, Jiyang Xue#, Qing Zhou, Yue Zhang, Mingming Zhang, Yuanjian Zhang, Hai Zhang*, Yanfei Shen*, Coupling Metal-Organic Framework Nanosphere and Nanobody for Boosted Photoelectrochemical Immunoassay of Human Epididymis Protein 4, Analytica Chimica Acta, 2020, 1107: 145-154. (Co-corresponding author, IF:6.911) 16. Zhong Wan#, Fangyuan Xie#, Liang Wang, Guoqing Zhang*, Hai Zhang*, Preparation and Evaluation of Cabazitaxel-Loaded Bovine Serum Albumin Nanoparticles for Prostate Cancer, International Journal of Nanomedicine, 2020,15:5333-5344. (Corresponding author, IF: 7.033) 17. Hai-Qiao Wang#, Min Liu#, Liang Wang, Fen Lan, Yi-Han Zhang, Jin-Er Xia, Zhen-Dong Xu*, Hai Zhang*, Identification of a novel BACE1 inhibitor, timosaponin A-III, for treatment of Alzheimer’s disease by a cell extraction and chemogenomics target knowledgebase-guided method, Phytomedicine, 2020,75:153244. (Corresponding author, IF:6.656)

—— 其他成果 ——

获奖 1. 药物复杂体系中活性物质分析关键技术研究及应用，中国药学会药学科技奖，二等奖，第3，2024年 2. 药物复杂体系中活性物质分析关键技术研究及应用，上海药学科技奖，二等奖，第3，2024年 专著 2. 《准爸准妈“药”知道》，中国科学技术出版社，主编，2024.6 3. 《儿童合理用药》，北京大学医学出版社，副主编，2021.9 4. 《妇产科临床药师实用手册》，复旦大学医学出版社，副主编，2021.1 5. 《妇幼保健院药事管理制度与规范》，人民卫生出版社，编委，2022.6 6. 《妊娠期哺乳期用药手册》，人民卫生出版社，编委，2023.8 专利 1. 一种用于预防宫腔再粘连的中药外敷组合物及其用途，发明专利，授权专利号：ZL 2022 1 1605346.5，第1 2. 中药复方“成分-靶点”智能分析系统，软件著作权，2018SR329709 3. 人D-二聚体的单域抗体及其应用发明专利，申请专利号：202510153734.1，第1 4. 人血栓调节蛋白的单域抗体及其应用，申请专利号：202510153656.5，第1 5. 苯甲酰新乌头原碱、苯甲酰乌头原碱、苯甲酰次乌头原碱在制备抗心衰药物中的应用，发明专利，申请专利号：201910164636.2，第1